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Allopurinol and Ziac

Determining the interaction of Allopurinol and Ziac and the possibility of their joint administration.

Check result:

Allopurinol <> Ziac

Relevance: 14.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking allopurinol, tell your doctor if you also use hydroCHLOROthiazide. You may need dose adjustments to safely take both medications together. You should notify your doctor if you have symptoms of a rash, itching, fever, or chills. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Serious hypersensitivity reactions to allopurinol have been well-documented in the medical literature. Case reports have suggested that thiazide diuretics may increase the risk of allopurinol-induced hypersensitivity reactions, especially in patients with renal insufficiency. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite).

MANAGEMENT: Patients should be advised to promptly report any signs of hypersensitivity, including rash, pruritus, fever, or chills.

References

Hande KR "Evaluation of a thiazide-allopurinol drug interaction." Am J Med Sci 292 (1986): 213-6
Devries JX, Voss A, Ittensohn A, Waltersack I, Loffler W, Landthaler R, Zollner N "Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects. 2. kinetics of allopurinol, oxipurinol, and hydrochlorothiazide." Clin Investig 72 (1994): 1076-81
Mills RM "Severe hypersensitivity reactions associated with allopurinol." JAMA 216 (1971): 799-802
Maschio G, Tessitore N, D'Angelo A, Fabris A, Pagano F, Tasca A, Graziani G, Aroldi A, Surian M, Colussi G, Mandressi A, Trinchieri ARocco F, Ponticel "Prevention of calcium nephrolithiasis with low-dose thiazide, amiloride and allopurinol." Am J Med 71 (1981): 623-6
Loffler W, Landthaler R, Devries JX, Waltersack I, Ittensohn A, Voss A, Zollner N "Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects." Clin Investig 72 (1994): 1071-5

Allopurinol

Generic Name: allopurinol

Brand name: Zyloprim, Lopurin, Aloprim

Synonyms: n.a.

What is Allopurinol?

Ziac

Generic Name: bisoprolol / hydrochlorothiazide

Brand name: Ziac

Synonyms: n.a.

What is Ziac?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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