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Allopurinol Intravenous and Probenecid Tablets

Determining the interaction of Allopurinol Intravenous and Probenecid Tablets and the possibility of their joint administration.

Check result:

Allopurinol Intravenous <> Probenecid Tablets

Relevance: 02.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Probenecid may increase the renal excretion of oxypurinol, the active metabolite of allopurinol, while allopurinol may inhibit probenecid metabolism. The clinical significance is unknown. Patients should be monitored for altered effects of both drugs.

References

Tjandramaga TB, Cucinell SA, Israili ZH, et al "Observations on the disposition of probenecid in patients receiving allopurinol." Pharmacology 8 (1972): 259-72
Kelley WN "Current therapy of gout and hyperuricemia." Hosp Pract 11 (1976): 69-76
Elion GB, Yu TF, Gutman AB, Hitchings GH "Renal clearance of oxipurinol, the chief metabolite of allopurinol." Am J Med 45 (1968): 69-77

Allopurinol Intravenous

Generic Name: allopurinol

Brand name: Zyloprim, Lopurin, Aloprim

Synonyms: Allopurinol

What is Allopurinol Intravenous?

Probenecid Tablets

Generic Name: probenecid

Brand name: Benemid

Synonyms: Probenecid

What is Probenecid Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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