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Allopurinol Intravenous and Theo-Dur

Determining the interaction of Allopurinol Intravenous and Theo-Dur and the possibility of their joint administration.

Check result:

Allopurinol Intravenous <> Theo-Dur

Relevance: 02.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Allopurinol may inhibit the metabolism of the xanthines, possibly increasing serum concentrations and the risk of toxicity. This interaction may be more likely to occur with daily allopurinol doses of 600 mg or more. The mechanism is unknown and data from controlled studies have been conflicting. Patients receiving this combination should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physician.

References

Barry M, Feely J "Allopurinol influences aminophenazone elimination." Clin Pharmacokinet 19 (1990): 167
Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet 20 (1991): 135-50
Manfredi RL, Vesell ES "Inhibition of theophylline metabolism by long-term allopurinol administration." Clin Pharmacol Ther 29 (1981): 224

Allopurinol Intravenous

Generic Name: allopurinol

Brand name: Zyloprim, Lopurin, Aloprim

Synonyms: Allopurinol

What is Allopurinol Intravenous?

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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