Allopurinol Tablets and Fosphenytoin Sodium
Determining the interaction of Allopurinol Tablets and Fosphenytoin Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited clinical data suggest that allopurinol may increase phenytoin serum concentrations. The mechanism is unknown and causality is unclear. It is not known whether ethotoin and mephenytoin, which are similar hydantoin compounds, also participate in this interaction. The patient should be monitored for signs of phenytoin toxicity when allopurinol is added to an established phenytoin regimen. Patients should be advised to notify their physician if they experience symptoms of possible hydantoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia.
- Yokochi K, Yokochi A, Chiba K, Ishizaki T "Phenytoin-allopurinol interaction: Michaelis-Menten kinetic parameters of phenytoin with and without allopurinol in a child with Lesch-Nyhan syndrome." Ther Drug Monit 4 (1982): 353-7
Generic Name: allopurinol
Brand name: Zyloprim, Lopurin, Aloprim
Synonyms: Allopurinol
Generic Name: fosphenytoin
Brand name: Cerebyx
Synonyms: Fosphenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Allopurinol Tablets-Fospropofol Intravenous
- Allopurinol Tablets-Fosrenol
- Allopurinol Tablets-Fosrenol (Lanthanum Chewable Tablets)
- Allopurinol Tablets-Fosrenol (Lanthanum Powder)
- Allopurinol Tablets-Fostamatinib
- Allopurinol Tablets-Fostamatinib disodium
- Fosphenytoin Sodium-Allzital
- Fosphenytoin Sodium-Almacone
- Fosphenytoin Sodium-Almotriptan
- Fosphenytoin Sodium-Almotriptan Malate
- Fosphenytoin Sodium-Alodox
- Fosphenytoin Sodium-Aloe polysaccharides, hydrocortisone, and iodoquinol topical