Alogliptin and metformin and Pitolisant Hydrochloride
Determining the interaction of Alogliptin and metformin and Pitolisant Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with pitolisant may increase plasma concentrations of substrates of the hepatic and intestinal uptake transporter, organic cation transporter 1 (OCT1). Pitolisant has demonstrated inhibitory potential towards OCT1 in vitro. The clinical significance of this effect has not been established. MANAGEMENT: Caution is recommended when pitolisant is administered with OCT1 substrates. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Professional:MONITOR: Coadministration with pitolisant may increase plasma concentrations of substrates of the hepatic and intestinal uptake transporter, organic cation transporter 1 (OCT1). Pitolisant has demonstrated inhibitory potential towards OCT1 in vitro. The clinical significance of this effect has not been established.
MANAGEMENT: Caution is recommended when pitolisant is administered with OCT1 substrates.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: alogliptin / metformin
Brand name: Kazano
Synonyms: Alogliptin and Metformin
Generic Name: pitolisant
Brand name: Wakix
Synonyms: Pitolisant
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Alogliptin and metformin-Pitressin
- Alogliptin and metformin-Pitressin Injection
- Alogliptin and metformin-Pitressin Synthetic
- Alogliptin and metformin-Placidyl
- Alogliptin and metformin-Plan B
- Alogliptin and metformin-Plan B One-Step
- Pitolisant Hydrochloride-Alogliptin and Metformin Tablets
- Pitolisant Hydrochloride-Alogliptin and pioglitazone
- Pitolisant Hydrochloride-Alogliptin and Pioglitazone Tablets
- Pitolisant Hydrochloride-Alogliptin Benzoate
- Pitolisant Hydrochloride-Aloprim
- Pitolisant Hydrochloride-Aloquin