Alogliptin Benzoate and Belbuca

• Generic Name: alogliptin
• Dosage Forms: n.a.
• Other Brand Names: Nesina

Used as monotherapy as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Used in combination with pioglitazone (given separately or as the fixed combination) as initial therapy as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus when treatment with both alogliptin and pioglitazone is appropriate.

Used in combination with metformin (given separately or as the fixed combination) as initialtherapy as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus when treatment with both alogliptin and metformin is appropriate.

Used in combination with other oral antidiabetic agents (e.g., metformin, a sulfonylurea, a thiazolidinedione [peroxisome proliferator-activated receptor-γ agonist]) or insulin as an adjunct to diet and exercise in patients with type 2 diabetes mellitus who have not achieved adequate glycemic control.

American Association of Clinical Endocrinologists/American College of Endocrinology (AACE/ACE) suggests a DPP-4 inhibitor as one of several alternatives for initial monotherapy in patients with metformin contraindications (e.g., renal disease, hepatic disease, GI intolerance, risk of lactic acidosis). DPP-4 inhibitors also recommended as part of combination therapy, particularly when both postprandial and fasting plasma glucose concentrations are elevated.

Not indicated for use in patients with type 1 diabetes mellitus or diabetic ketoacidosis.

• Generic Name: buprenorphine
• Dosage Forms: buccal film
• Other Brand Names: Belbuca, Buprenex, Probuphine, Butrans, Sublocade, Subutex

Belbuca buccal films contain buprenorphine, an opioid medication. An opioid is sometimes called a narcotic.

Belbuca buccal films are for around-the-clock treatment of moderate to severe chronic pain that is not controlled by other medicines.

Belbuca is not for use on an as-needed basis for occasional pain.

The Belbuca buccal film is placed between the gum and cheek where it adheres to the moist buccal mucosa to deliver the medicine as the film dissolves.