Alogliptin Benzoate and EndaCof-C

• Generic Name: alogliptin
• Dosage Forms: n.a.
• Other Brand Names: Nesina

Used as monotherapy as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Used in combination with pioglitazone (given separately or as the fixed combination) as initial therapy as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus when treatment with both alogliptin and pioglitazone is appropriate.

Used in combination with metformin (given separately or as the fixed combination) as initialtherapy as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus when treatment with both alogliptin and metformin is appropriate.

Used in combination with other oral antidiabetic agents (e.g., metformin, a sulfonylurea, a thiazolidinedione [peroxisome proliferator-activated receptor-γ agonist]) or insulin as an adjunct to diet and exercise in patients with type 2 diabetes mellitus who have not achieved adequate glycemic control.

American Association of Clinical Endocrinologists/American College of Endocrinology (AACE/ACE) suggests a DPP-4 inhibitor as one of several alternatives for initial monotherapy in patients with metformin contraindications (e.g., renal disease, hepatic disease, GI intolerance, risk of lactic acidosis). DPP-4 inhibitors also recommended as part of combination therapy, particularly when both postprandial and fasting plasma glucose concentrations are elevated.

Not indicated for use in patients with type 1 diabetes mellitus or diabetic ketoacidosis.

• Generic Name: chlorpheniramine / codeine
• Dosage Forms: oral liquid
• Other Brand Names: Codar AR, EndaCof-C, Lexuss 210, Z-Tuss AC, Tuzistra XR, Codeprex, Cotab A, Cotab AX, Notuss-AC, Zodryl AC 25, Zodryl AC 30, Zodryl AC 35, Zodryl AC 50, Zodryl AC 40, Zodryl AC 60, Zodryl AC 80, EndaCof-C, TL-Hist CM, Zodryl AC Adult, Tuxarin ER

• This medicine is not for use in children younger than 18 years of age. The benefits of taking EndaCof-C (codeine and chlorpheniramine liquid) for a cough due to allergies, a cold, or other infection do not outweigh the risks in children. If your child has been given EndaCof-C (codeine and chlorpheniramine liquid) or if you have any questions, talk with your child's doctor.