Aloprim and Aminophylline injection
Determining the interaction of Aloprim and Aminophylline injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Allopurinol may inhibit the metabolism of the xanthines, possibly increasing serum concentrations and the risk of toxicity. This interaction may be more likely to occur with daily allopurinol doses of 600 mg or more. The mechanism is unknown and data from controlled studies have been conflicting. Patients receiving this combination should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physician.
- Barry M, Feely J "Allopurinol influences aminophenazone elimination." Clin Pharmacokinet 19 (1990): 167
- Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet 20 (1991): 135-50
- Manfredi RL, Vesell ES "Inhibition of theophylline metabolism by long-term allopurinol administration." Clin Pharmacol Ther 29 (1981): 224
Generic Name: allopurinol
Brand name: Aloprim, Zyloprim, Lopurin
Synonyms: n.a.
Generic Name: aminophylline
Brand name: Phyllocontin, Truphylline
Synonyms: Aminophylline (injection), Aminophylline
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aloprim-Aminophylline Intravenous
- Aloprim-Aminophylline Oral Solution
- Aloprim-Aminophylline Tablets
- Aloprim-AminoProtect
- Aloprim-Aminosalicylate sodium
- Aloprim-Aminosalicylic Acid
- Aminophylline injection-Aloquin
- Aminophylline injection-Aloquin Gel
- Aminophylline injection-Alora
- Aminophylline injection-Alora Transdermal
- Aminophylline injection-Alosetron
- Aminophylline injection-Alosetron Hydrochloride