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Aloprim and Gengraf Capsules

Determining the interaction of Aloprim and Gengraf Capsules and the possibility of their joint administration.

Check result:
Aloprim <> Gengraf Capsules
Relevance: 10.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using allopurinol together with cycloSPORINE can increase the levels of cycloSPORINE. Tell your doctor if you experience dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage. Talk with your doctor if you develop fever, chills, body aches, flu symptoms, and severe pain in your upper stomach spreading to your back. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant administration of allopurinol may increase cyclosporine blood concentrations. The mechanism is unknown. The risk of cyclosporine-induced nephrotoxicity and neurotoxicity may be increased.

MANAGEMENT: Cyclosporine levels and renal function, including serum creatinine, should be carefully monitored. The dosage should be adjusted as needed. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.

References
  • "Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
  • Gorrie M, Beaman M, Nicholls A, Backwell P "Allopurinol interaction with cyclosporin." Br Med J 308 (1994): 113
Aloprim

Generic Name: allopurinol

Brand name: Aloprim, Zyloprim, Lopurin

Synonyms: n.a.

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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