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Aloprim and Treanda

Determining the interaction of Aloprim and Treanda and the possibility of their joint administration.

Check result:
Aloprim <> Treanda
Relevance: 10.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using allopurinol together with bendamustine may increase the risk of rare but serious and life-threatening skin reactions. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Contact your doctor immediately if you develop a rash or other skin reactions during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of bendamustine with allopurinol may increase the risk of severe skin reactions. Rare cases of Stevens-Johnson syndrome and toxic epidermal necrolysis, some fatal, have been reported when bendamustine was administered concomitantly with allopurinol and other medications known to be associated with these toxicities. The potential mechanism of interaction has not been established.

MANAGEMENT: Although allopurinol may be given to prevent tumor lysis syndrome during treatment with bendamustine, caution is advised when these medications are used together. Because skin reactions may be progressive and increase in severity with further treatment, patients who develop skin reactions should be closely monitored. The manufacturer recommends that bendamustine be withheld or discontinued if skin reactions are severe or progressive.

References
  • "Product Information. Bendeka (bendamustine)." Teva Pharmaceuticals USA, North Wales, PA.
  • "Product Information. Treanda (bendamustine)." Cephalon Inc, West Chester, PA.
Aloprim

Generic Name: allopurinol

Brand name: Aloprim, Zyloprim, Lopurin

Synonyms: n.a.

Treanda

Generic Name: bendamustine

Brand name: Treanda, Belrapzo, Bendeka

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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