Alosetron Hydrochloride and Ertapenem Sodium

• Generic Name: alosetron
• Dosage Forms: n.a.
• Other Brand Names: Lotronex

Only for management of severe diarrhea-predominant IBS in women with chronic symptoms (generally lasting ≥6 months) who have had anatomic or biochemical GI abnormalities excluded and have not responded to conventional therapy. Diarrhea-predominant IBS is considered severe if accompanied by at least one of the following symptoms: frequent and severe abdominal pain and/or discomfort; frequent bowel urgency or fecal incontinence; or disability or restriction of daily activities.

Use restricted to patients for whom benefit-to-risk balance is considered to be most favorable. (See Boxed Warning.)

Efficacy in men not adequately demonstrated in clinical studies.

• Generic Name: ertapenem
• Dosage Forms: n.a.
• Other Brand Names: Invanz, INVanz ADD-Vantage

Treatment of moderate to severe acute pelvic infections (including postpartum endomyometritis, septic abortion, postsurgical infections) caused by susceptible Streptococcus agalactiae (group B streptococci), Escherichia coli, Bacteroides fragilis, Porphyromonas asaccharolytica, Peptostreptococcus, or Prevotella bivia.

Treatment of complicated intra-abdominal infections caused by susceptible E. coli, Clostridium clostridioforme, Eubacterium lentum, Peptostreptococcus, B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, or B. uniformis.

Treatment of moderate to severe community-acquired pneumonia (CAP) caused by susceptible Streptococcus pneumoniae (penicillin-susceptible strains only), including cases with concurrent bacteremia.

Treatment of moderate to severe CAP caused by susceptible Haemophilus influenzae (non-β-lactamase-producing strains only) or Moraxella catarrhalis.

Treatment of complicated skin and skin structure infections, including diabetic foot infections without concurrent osteomyelitis, caused by susceptible Staphylococcus aureus (oxacillin-susceptible [methicillin-susceptible] strains only), Streptococcus agalactiae, S. pyogenes (group A β-hemolytic streptococci), E. coli, Klebsiella pneumoniae, Proteus mirabilis, Bacteroides fragilis, Peptostreptococcus species, Porphyromonas asaccharolytica, or Prevotella bivia.

Treatment of complicated UTIs (including pyelonephritis) caused by susceptible E. coli (including cases with concurrent bacteremia) or Klebsiella pneumoniae.