Alosetron Hydrochloride and Glycerol phenylbutyrate

• Generic Name: alosetron
• Dosage Forms: n.a.
• Other Brand Names: Lotronex

Only for management of severe diarrhea-predominant IBS in women with chronic symptoms (generally lasting ≥6 months) who have had anatomic or biochemical GI abnormalities excluded and have not responded to conventional therapy. Diarrhea-predominant IBS is considered severe if accompanied by at least one of the following symptoms: frequent and severe abdominal pain and/or discomfort; frequent bowel urgency or fecal incontinence; or disability or restriction of daily activities.

Use restricted to patients for whom benefit-to-risk balance is considered to be most favorable. (See Boxed Warning.)

Efficacy in men not adequately demonstrated in clinical studies.

• Generic Name: glycerol phenylbutyrate
• Dosage Forms: n.a.
• Other Brand Names: Ravicti

Glycerol phenylbutyrate binds with other substances in the liver and kidneys to help eliminate nitrogen from the body. Excess nitrogen can cause hyperammonemia (HYE-per-AM-moe-NEE-mee-a), a build-up of ammonia in the blood. Ammonia is very toxic when it circulates in blood and tissues and can cause permanent brain damage, coma, or death.

Glycerol phenylbutyrate helps prevent a build-up of ammonia in the blood in people with urea cycle disorder. glycerol phenylbutyrate is used in adults and children who are at least 2 months old. Glycerol phenylbutyrate will not treat hyperammonemia.

Glycerol phenylbutyrate is usually given together with a low-protein diet and sometimes dietary supplements.

Glycerol phenylbutyrate may also be used for purposes not listed in this medication guide.