Alpelisib and Se-Donna PB Hyos
Determining the interaction of Alpelisib and Se-Donna PB Hyos and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration of alpelisib with potent inducers of CYP450 3A4 may significantly reduce the plasma concentrations of alpelisib. The proposed mechanism, based on in vitro data, is increased clearance due to induction of CYP450 3A4, which is one of the routes of metabolism of alpelisib. The therapeutic efficacy of alpelisib may be reduced; however, clinical data are lacking. MANAGEMENT: According to the manufacturer, concomitant use of alpelisib with potent CYP450 3A4 inducers should generally be avoided. Alternative therapeutic agents with less enzyme induction potential should be considered. References "Product Information. Piqray (alpelisib)." Novartis Pharmaceuticals, East Hanover, NJ.
Professional:GENERALLY AVOID: Coadministration of alpelisib with potent inducers of CYP450 3A4 may significantly reduce the plasma concentrations of alpelisib. The proposed mechanism, based on in vitro data, is increased clearance due to induction of CYP450 3A4, which is one of the routes of metabolism of alpelisib. The therapeutic efficacy of alpelisib may be reduced; however, clinical data are lacking.
MANAGEMENT: According to the manufacturer, concomitant use of alpelisib with potent CYP450 3A4 inducers should generally be avoided. Alternative therapeutic agents with less enzyme induction potential should be considered.
- "Product Information. Piqray (alpelisib)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Se-Donna PB Hyos (Oral), Se-Donna Pb Hyos
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Alpelisib-Se-Natal 19
- Alpelisib-Se-Plus Protein
- Alpelisib-Se-Tan DHA
- Alpelisib-Se-Tan Plus
- Alpelisib-Sea Buddies Daily Multiple Vitamin
- Alpelisib-Seasonale
- Se-Donna PB Hyos-Alph-E
- Se-Donna PB Hyos-Alph-E-Mixed
- Se-Donna PB Hyos-Alph-E-Mixed 1000
- Se-Donna PB Hyos-Alpha Lipoic Acid
- Se-Donna PB Hyos-Alpha-E
- Se-Donna PB Hyos-Alphagan P