Alprazolam Intensol and Noxafil (Posaconazole Oral Suspension)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ALPRAZolam together with posaconazole can increase the effects of ALPRAZolam. This can cause extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, or coma. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with posaconazole may significantly increase the plasma concentrations and pharmacologic effects of benzodiazepines that are primarily metabolized by CYP450 3A4. The mechanism is increased bioavailability and/or decreased clearance due to inhibition of intestinal and hepatic CYP450 3A4 by posaconazole. According to product labeling, pretreatment with posaconazole (200 mg tablets once a day for 10 days) increased the systemic exposure (AUC) of a single 0.05 mg/kg intravenous dose of midazolam by 83%. A greater effect is expected with oral midazolam. The interaction is subject to a high degree of interpatient variability.

MANAGEMENT: The benzodiazepine dose may require reduction during concomitant administration with posaconazole. Monitoring for increased benzodiazepine effects is recommended, and the dosage adjusted as necessary. Alternatively, benzodiazepines that are not metabolized by CYP450 3A4 (e.g., lorazepam, oxazepam, temazepam) may be considered in patients requiring posaconazole treatment.

Alprazolam Intensol

Generic Name: alprazolam

Brand name: Alprazolam Intensol, Niravam, Xanax, Xanax XR

Synonyms: n.a.

What is Alprazolam Intensol?

Noxafil (Posaconazole Oral Suspension)

Generic Name: posaconazole

Brand name: Noxafil

Synonyms: Noxafil

What is Noxafil (Posaconazole Oral Suspension)?