Alprazolam ODT and Fluvoxamine Maleate
Determining the interaction of Alprazolam ODT and Fluvoxamine Maleate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using ALPRAZolam together with fluvoxaMINE may increase the effects of ALPRAZolam. Contact your doctor if you experience extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Administration of fluvoxamine with certain benzodiazepines may increase CNS depression (e.g., sedation, ataxia). The mechanism appears to be inhibition of the CYP450 3A4 hepatic oxidative metabolism of the benzodiazepine. This interaction has been reported for alprazolam and diazepam, but may also occur with other benzodiazepines.
MANAGEMENT: The patient should be observed for increased CNS depression. Dosage adjustments may be required. Lorazepam, temazepam, and oxazepam, which are not metabolized by oxidative metabolism, may be better alternatives if a benzodiazepine is required.
- Fleishaker JC, Hulst LK "A pharmacokinetic and pharmacodynamic evaluation of the combined administration of alprazolam and fluvoxamine." Eur J Clin Pharmacol 46 (1994): 35-9
- "Product Information. Luvox (fluvoxamine)." Solvay Pharmaceuticals Inc, Marietta, GA.
- Vonmoltke LL, Greenblatt DJ, Court MH, Duan SX, Harmatz JS, Shader RI "Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants." J Clin Psychopharmacol 15 (1995): 125-31
Generic Name: alprazolam
Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol
Synonyms: Alprazolam, ALPRAZolam
Generic Name: fluvoxamine
Brand name: Luvox, Luvox CR
Synonyms: Fluvoxamine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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