Alprazolam Oral and Zoloft
Determining the interaction of Alprazolam Oral and Zoloft and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Sertraline may increase plasma alprazolam concentrations by inhibiting its CYP450 3A4 metabolism. In healthy subjects, there were no pharmacokinetic changes and there were slight decreases in a driving simulation test score. The clinical significance is believed to be minor.
- Vonmoltke LL, Greenblatt DJ, Cotreaubibbo MM, Harmatz JS, Shader RI "Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine." Br J Clin Pharmacol 38 (1994): 23-31
- Hassan PC, Sproule BA, Naranjo CA, Herrmann N "Dose-response evaluation of the interaction between sertraline and alprazolam in vivo." J Clin Psychopharmacol 20 (2000): 150-8
- Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
Generic Name: alprazolam
Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol
Synonyms: Alprazolam, ALPRAZolam
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Alprazolam Oral-Zoloft (Sertraline Oral Liquid)
- Alprazolam Oral-Zoloft (Sertraline Tablets)
- Alprazolam Oral-Zolpidem
- Alprazolam Oral-Zolpidem Extended Release
- Alprazolam Oral-Zolpidem Extended-Release Tablets
- Alprazolam Oral-Zolpidem Oral Spray
- Zoloft-Alprazolam Oral Solution
- Zoloft-Alprazolam Orally Disintegrating Tablets
- Zoloft-Alprazolam Tablets
- Zoloft-Alprazolam XR
- Zoloft-Alprolix
- Zoloft-Alprolix Intravenous