Alteplase and Amlodipine and perindopril
Determining the interaction of Alteplase and Amlodipine and perindopril and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using alteplase together with perindopril may cause angioedema, a condition associated with swelling of the face, eyes, lips, tongue, throat, and occasionally also the hands and feet. Each medication alone can also cause angioedema, but the risk may be increased when they are combined. Angioedema can occur with the first dose of medication or after many doses. You should discontinue the medications and seek immediate medical attention if you develop symptoms of angioedema or have difficulty swallowing or breathing. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of a tissue plasminogen activator with an angiotensin enzyme converting (ACE) inhibitor may increase the risk of angioedema and anaphylactoid reactions. The mechanism is unknown. Cases of orolingual angioedema have been associated with alteplase administration; many of these patients were also receiving ACE inhibitors.
MANAGEMENT: It is recommended to monitor patients for adverse reactions during concomitant therapy.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Activase (alteplase)." Genentech, South San Francisco, CA.
Generic Name: alteplase
Brand name: Activase, Cathflo Activase
Synonyms: n.a.
Generic Name: amlodipine / perindopril
Brand name: Prestalia
Synonyms: Perindopril and Amlodipine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Alteplase-Amlodipine Suspension
- Alteplase-Amlodipine Tablets
- Alteplase-Amlodipine, hydrochlorothiazide, and olmesartan
- Amlodipine and perindopril-Alteplase (Catheter Clearance)
- Amlodipine and perindopril-Alteplase (Injection)
- Amlodipine and perindopril-Alteplase, recombinant Intravenous
- Amlodipine and perindopril-Alti-Alprazolam Oral
- Amlodipine and perindopril-Alti-Amoxi Clav
- Amlodipine and perindopril-Alti-Haloperidol