Alti-Valproic and Tiagabine Hydrochloride
Determining the interaction of Alti-Valproic and Tiagabine Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Tiagabine has been reported to cause a 10% decrease in serum valproate concentrations. Additionally, valproic acid decreased tiagabine protein binding in vitro from 96.3% to 94.4% which resulted in a 40% increase in free tiagabine levels. The clinical significance of either interaction is unknown. However, clinical and/or laboratory monitoring for evidence of altered effect of both drugs is recommended if this combination is used.
- "Product Information. Gabitril (tiagabine)." Abbott Pharmaceutical, Abbott Park, IL.
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Valproic acid, Valproic Acid and Derivatives
Generic Name: tiagabine
Brand name: Gabitril
Synonyms: Tiagabine, TiaGABine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Alti-Valproic-Tiagabine Tablets
- Alti-Valproic-Tiamol
- Alti-Valproic-Tiazac
- Alti-Valproic-Tibsovo
- Alti-Valproic-Ticagrelor
- Alti-Valproic-Ticalast
- Tiagabine Hydrochloride-Altocor
- Tiagabine Hydrochloride-Altoprev
- Tiagabine Hydrochloride-Altreno
- Tiagabine Hydrochloride-Altreno Topical
- Tiagabine Hydrochloride-Altretamine
- Tiagabine Hydrochloride-Aluminum hydroxide