Altocor and Tolvaptan (Jynarque/Jinarc)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with tolvaptan may increase the plasma concentrations of lovastatin and its active metabolite, lovastatin beta-hydroxyacid. The mechanism is tolvaptan inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of lovastatin as well as the metabolite. According to the tolvaptan product labeling, administration of lovastatin in combination with tolvaptan increased the systemic exposure to lovastatin and lovastatin beta-hydroxyacid by 1.4- and 1.3-fold, respectively. These changes are not considered clinically significant.

Altocor

Generic Name: lovastatin

Brand name: Altocor, Altoprev, Mevacor

Synonyms: n.a.

What is Altocor?

Tolvaptan (Jynarque/Jinarc)

Generic Name: tolvaptan

Brand name: Samsca, Jynarque

Synonyms: Tolvaptan

What is Tolvaptan (Jynarque/Jinarc)?