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Altretamine and Prenaissance Next-B

Determining the interaction of Altretamine and Prenaissance Next-B and the possibility of their joint administration.

Check result:
Altretamine <> Prenaissance Next-B
Relevance: 26.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using pyridoxine together with altretamine. Using these medications together may cause altretamine to be less effective. Contact your doctor if you condition worsens. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Data from a randomized trial of altretamine and cisplatin in ovarian cancer indicated that pyridoxine significantly reduced neurotoxicity but also adversely affected response duration. The mechanism of interaction has not been established.

MANAGEMENT: Until further data are available, it may be advisable to avoid using altretamine with pyridoxine.

References
  • Wiernik PH, Yeap B, Vogl SE, et al "Hexamethylmelamine and low or moderate dose cisplatin with or without pyridoxine for treatment of advanced ovarian carcinoma: a study of the Eastern Cooperative Oncology Group." Cancer Invest 10 (1992): 1-9
  • "Product Information. Hexalen Capsules (altretamine)." US Bioscience, West Conshohoken, PA.
Altretamine

Generic Name: altretamine

Brand name: Hexalen

Synonyms: n.a.

Prenaissance Next-B

Generic Name: calcium / folic acid / ginger / pyridoxine

Brand name: Prenaissance Next, Prenaissance Next-B

Synonyms: Vitamin B6, Ginger, Folic Acid, and Calcium

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction