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Altretamine and Seconal Sodium

Determining the interaction of Altretamine and Seconal Sodium and the possibility of their joint administration.

Check result:

Altretamine <> Seconal Sodium

Relevance: 26.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using altretamine together with secobarbital. Using these medications together may cause altretamine to be less effective. Contact your doctor if you condition worsens. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: According to a rat model, the coadministration with phenobarbital (PB) may decrease the plasma, liver, and tumor concentrations of altretamine, as well as reduce its antitumor activity. The likely mechanism is PB induction of altretamine metabolism via CYP450 isoenzymes, resulting in decreased time of exposure of tumor cells to altretamine and its active metabolites. In the study, mice pretreated with PB had altretamine plasma, liver, and tumor area under the concentration-time curve (AUC) values that were 17%, 17%, and 34%, respectively, of those observed in the control group. AUCs for almost all of the metabolites were also much lower compared to controls. In addition, PB pretreatment reduced the effectiveness of altretamine as reflected in tumor weight reduction.

MANAGEMENT: Until further data are available, the concomitant use of altretamine and phenobarbital should probably be avoided if possible. The same precaution may be applicable to other barbiturates because of their potential to induce CYP450 isoenzymes.

References

Paolini A, D'Incalci M "Effect of phenobarbital pretreatment on the metabolism and antitumor activity of hexamethylmelamine." Cancer Treat Rep 70 (1986): 513-6

Altretamine

Generic Name: altretamine

Brand name: Hexalen

Synonyms: n.a.

What is Altretamine?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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