Aluminum Hydroxide and Magnesium Carbonate Chewable Tablets and Phenergan injection
Determining the interaction of Aluminum Hydroxide and Magnesium Carbonate Chewable Tablets and Phenergan injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with aluminum- or magnesium-containing antacids may decrease the serum concentrations of orally administered phenothiazines. The proposed mechanism is antacid adsorption resulting in reduced phenothiazine bioavailability. The interaction has been reported for chlorpromazine but may occur with other phenothiazines. In a study of ten patients treated with chlorpromazine, 30 mL of an antacid containing aluminum and magnesium hydroxide reduced the urinary excretion of chlorpromazine by 10% to 45%. In another study with six psychiatric patients, coadministration of chlorpromazine oral suspension with 30 mL of an antacid containing aluminum hydroxide and magnesium trisilicate resulted in a 20% reduction in serum chlorpromazine level two hours later. The clinical significance is unknown. Psychiatric relapse occurred in a chlorpromazine-treated patient following the addition of antacid therapy according to a single case report. Separating the times of administration by 2 to 3 hours may help if an interaction is suspected.
- Forrest FM, Forrest IS, Serra MT "Modification of chlorpromazine metabolism by some other drugs frequently administered to psychiatric patients." Biol Psychiatry 2 (1970): 53-8
- Fann WE "Interactions of psychotropic drugs in the elderly." Postgrad Med 53 (1973): 182-6
- Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993):
- Fann WE, Davis JM, Janowsky DS, Sekerke HJ, Schmidt DM "Chlorpromazine: effects of antacids on its gastrointestinal absorption." J Clin Pharmacol 13 (1973): 388-90
- Romankiewicz JA "Effects of antacids on gastrointestinal absorption of drugs." Prim Care 3 (1976): 537-50
Generic Name: aluminum hydroxide / magnesium carbonate
Brand name: Gaviscon Extra Relief Formula, Acid Gone, Gaviscon
Synonyms: n.a.
Generic Name: promethazine
Brand name: Phenergan, Phenadoz, Promethegan
Synonyms: Phenergan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Aluminum Hydroxide and Magnesium Carbonate Chewable Tablets-Phenergan VC
- Aluminum Hydroxide and Magnesium Carbonate Chewable Tablets-Phenergan w/Codeine
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- Phenergan injection-Aluminum Hydroxide and Magnesium Hydroxide Suspension
- Phenergan injection-Aluminum Hydroxide and Magnesium Trisilicate
- Phenergan injection-Aluminum hydroxide, magnesium hydroxide, and simethicone
- Phenergan injection-Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Chewable Tablets