Aluminum Hydroxide and Magnesium Carbonate Suspension and Captopril Tablets
Determining the interaction of Aluminum Hydroxide and Magnesium Carbonate Suspension and Captopril Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with antacids may decrease the oral bioavailability of captopril and other angiotensin converting enzyme (ACE) inhibitors due to delayed gastric emptying and/or elevated gastric pH. In 10 healthy volunteers, 50 mL of an antacid suspension decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of captopril (50 mg single oral dose) by 50% and 42%, respectively, compared to administration after fasting. The relative bioavailability of captopril was 0.66 with antacid, although its hypotensive activity did not seem to be affected. Based on available data, the clinical significance of this interaction appears to be minor. As a precaution, patients may want to consider separating the administration times of ACE inhibitors and antacids or oral medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution) by 1 to 2 hours.
- Mantyla R, Mannisto PT, Vuorela A, Sundberg S, Ottoila P "Impairment of captopril bioavailability by concomitant food and antacid intake." Int J Clin Pharmacol Ther Toxicol 22 (1984): 626-9
Generic Name: aluminum hydroxide / magnesium carbonate
Brand name: Gaviscon Extra Relief Formula, Acid Gone, Gaviscon
Synonyms: Aluminum Hydroxide and Magnesium Carbonate Chewable Tablets
Generic Name: captopril
Brand name: Capoten
Synonyms: Captopril
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Captracin
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Captracin Patch
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Capzasin
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Capzasin Back and Body
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Capzasin Quick Relief
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Capzasin-HP
- Captopril Tablets-Aluminum Hydroxide and Magnesium Hydroxide Chewable Tablets
- Captopril Tablets-Aluminum Hydroxide and Magnesium Hydroxide Suspension
- Captopril Tablets-Aluminum Hydroxide and Magnesium Trisilicate
- Captopril Tablets-Aluminum hydroxide, magnesium hydroxide, and simethicone
- Captopril Tablets-Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Chewable Tablets
- Captopril Tablets-Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Suspension