Aluminum Hydroxide and Magnesium Carbonate Suspension and Nerlynx
Determining the interaction of Aluminum Hydroxide and Magnesium Carbonate Suspension and Nerlynx and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:By reducing the acidity level in the stomach, aluminum hydroxide may interfere with the absorption of neratinib and reduce its effectiveness. Talk to your doctor or pharmacist if you have any questions or concerns. You may need to adjust the timing of your medication doses to minimize the interaction. It has been recommended to take neratinib three hours after an antacid dose. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with drugs that increase gastric pH may significantly decrease the oral bioavailability of neratinib. The solubility of neratinib is pH-dependent and increases as neratinib becomes protonated at acidic pH, thus an increase in pH may interfere with its absorption. According to the product labeling, neratinib is sparingly soluble at pH 1.2 (32.90 mg/mL) and insoluble at approximate pH 5.0 and above (0.08 mg/mL or less). When a single 240 mg dose of neratinib was administered to 15 healthy adult subjects on day 5 of treatment with lansoprazole 30 mg orally once daily for 7 days, mean neratinib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 71% and 65%, respectively, compared to neratinib administered alone. Concomitant use with other pH lowering agents was not studied, but a decrease in neratinib AUC is also considered likely.
MANAGEMENT: Concomitant use of neratinib with drugs that increase gastric pH should generally be avoided. If acid-suppression therapy is required, short-acting antacids should be considered, with neratinib dosing separated by at least three hours after antacid administration.
- "Product Information. Nerlynx (neratinib)." Puma Biotechnology, Inc., Los Angeles, CA.
Generic Name: aluminum hydroxide / magnesium carbonate
Brand name: Gaviscon Extra Relief Formula, Acid Gone, Gaviscon
Synonyms: Aluminum Hydroxide and Magnesium Carbonate Chewable Tablets
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Neruo-K-500
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Nesacaine
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Nesacaine-MPF
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Nesina
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Nesiritide
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Nesiritide Intravenous
- Nerlynx-Aluminum Hydroxide and Magnesium Hydroxide Chewable Tablets
- Nerlynx-Aluminum Hydroxide and Magnesium Hydroxide Suspension
- Nerlynx-Aluminum Hydroxide and Magnesium Trisilicate
- Nerlynx-Aluminum hydroxide, magnesium hydroxide, and simethicone
- Nerlynx-Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Chewable Tablets
- Nerlynx-Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Suspension