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Aluminum Hydroxide and Magnesium Trisilicate and Isoniazid Injection

Determining the interaction of Aluminum Hydroxide and Magnesium Trisilicate and Isoniazid Injection and the possibility of their joint administration.

Check result:

Aluminum Hydroxide and Magnesium Trisilicate <> Isoniazid Injection

Relevance: 06.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Aluminum salts may slightly decrease the absorption of isoniazid. The mechanism is not known. To prevent this interaction, isoniazid should be administered one to two hours before administration of an aluminum-containing product.

References

Hurwitz A, Schlozman DL "Effects of antacids on gastrointestional absorption of isoniazid in rat and man." Am Rev Respir Dis 109 (1974): 41-7
Hava M, Hurwitz A "The relaxing effect of aluminum and lanthanum on rat and human gastric smooth muscle in vitro." Eur J Pharmacol 156 (1973): 156-61

Aluminum Hydroxide and Magnesium Trisilicate

Generic Name: aluminum hydroxide / magnesium trisilicate

Brand name: Drysol, Hypercare, Xerac AC, Gaviscon Tablet

Synonyms: n.a.

What is Aluminum Hydroxide and Magnesium Trisilicate?

Isoniazid Injection

Generic Name: isoniazid

Brand name: Nydrazid

Synonyms: Isoniazid

What is Isoniazid Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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