Amantadine and Reglan (Metoclopramide Injection Solution)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using amantadine together with metoclopramide. Combining these medications may reduce the effectiveness of both due to their opposing actions on the nervous system. Metoclopramide should generally be avoided if you are using amantadine for the treatment of Parkinson's disease or other movement disorders caused by certain medications. However, metoclopramide does not affect the use of amantadine for the treatment or prevention of influenza symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Metoclopramide may antagonize the pharmacologic effects of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions. Animal data suggest that amantadine may possess direct and indirect effects on dopamine neurons, and more recent studies have demonstrated that amantadine is a weak, noncompetitive NMDA (N-methyl-D-aspartate) receptor antagonist. In contrast, metoclopramide exhibits central antidopaminergic effects and augments NMDA activity. Adverse effects of metoclopramide include pseudoparkinsonism and extrapyramidal reactions, which are consistent with its pharmacologic effects. Conversely, amantadine may antagonize the actions of metoclopramide on the gastrointestinal tract due to its anticholinergic effects.

MANAGEMENT: Patients receiving amantadine for Parkinson's disease or drug-induced extrapyramidal reactions should generally avoid antidopaminergic agents including metoclopramide. If these agents have been administered together chronically, amantadine dosing should not be abruptly reduced or discontinued due to the potential to precipitate a parkinsonian crisis, delirium, agitation, delusions, hallucinations, paranoid reaction, stupor, anxiety, depression, slurred speech, and rarely, neuroleptic malignant syndrome. In patients receiving amantadine for influenza A prophylaxis or treatment, the possibility of diminished efficacy of metoclopramide should be considered during coadministration.

Amantadine

Generic Name: amantadine

Brand name: Gocovri, Osmolex ER, Symmetrel

Synonyms: n.a.

What is Amantadine?

Reglan (Metoclopramide Injection Solution)

Generic Name: metoclopramide

Brand name: Reglan, Metozolv ODT

Synonyms: Reglan

What is Reglan (Metoclopramide Injection Solution)?