Amantadine and Spironolactone and hydrochlorothiazide
Determining the interaction of Amantadine and Spironolactone and hydrochlorothiazide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data indicate that thiazide diuretics and/or triamterene may increase the probability of adverse reactions to amantadine. The mechanism is unknown but may be related to reduced clearance of amantadine, resulting in increased plasma levels. Possible reactions include ataxia, confusion, and agitation. If an interaction is suspected, the dosage of amantadine may be reduced or discontinued, or a different diuretic may be substituted.
- Wilson TW, Rajput AH "Amantadine-dyazide interaction." Can Med Assoc J 129 (1983): 974-5
Generic Name: amantadine
Brand name: Gocovri, Osmolex ER, Symmetrel
Synonyms: n.a.
Generic Name: hydrochlorothiazide / spironolactone
Brand name: Aldactazide
Synonyms: Hydrochlorothiazide and spironolactone, Hydrochlorothiazide and Spironolactone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amantadine-Spironolactone Oral Suspension
- Amantadine-Spironolactone Tablets
- Amantadine-SpongeBob SquarePants Gummies
- Amantadine-Sporanox
- Amantadine-Sporanox (Itraconazole Capsules (Sporanox))
- Amantadine-Sporanox (Itraconazole Oral Solution)
- Spironolactone and hydrochlorothiazide-Amantadine Capsules and Tablets
- Spironolactone and hydrochlorothiazide-Amantadine Extended-Release Capsules
- Spironolactone and hydrochlorothiazide-Amantadine Extended-Release Tablets
- Spironolactone and hydrochlorothiazide-Amantadine Hydrochloride
- Spironolactone and hydrochlorothiazide-Amantadine Oral Solution USP
- Spironolactone and hydrochlorothiazide-Amantadine Syrup