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Amantadine Capsules and Tablets and Quinidex Extentabs

Determining the interaction of Amantadine Capsules and Tablets and Quinidex Extentabs and the possibility of their joint administration.

Check result:

Amantadine Capsules and Tablets <> Quinidex Extentabs

Relevance: 20.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using amantadine together with quiNIDine may increase the effects of amantadine. Contact your doctor if you experience blurred vision, severe headache, nausea, vomiting, anxiety, confusion, aggression, tremor, fast or uneven heart rate, trouble breathing, or seizure (convulsion). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with quinine or quinidine may decrease the renal clearance of amantadine. The proposed mechanism is quinine and quinidine inhibition of the renal tubular secretion of amantadine. In 18 healthy volunteers administered a single oral dose of amantadine (3 mg/kg), renal clearance of amantadine decreased by approximately 27% and 32% within 6 hours after ingestion of a 200 mg dose of quinine or quinidine, respectively. The interaction was reported only in the male subjects and was not influenced by age.

MANAGEMENT: The potential for increased pharmacologic effects of amantadine, including adverse effects such as dizziness, confusion, ataxia, orthostatic hypotension, dry mouth, nausea and constipation, should be considered during coadministration with quinine or quinidine.

References

"Product Information. Symmetrel (amantadine)." DuPont Pharmaceuticals, Wilmington, DE.
Gaudry SE, Sitar DS, Smyth DD, McKenzie JK, Aoki FY "Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine." Clin Pharmacol Ther 54 (1993): 23-7

Amantadine Capsules and Tablets

Generic Name: amantadine

Brand name: Gocovri, Osmolex ER, Symmetrel

Synonyms: Amantadine

What is Amantadine Capsules and Tablets?

Quinidex Extentabs

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quinidex Extentabs?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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