Amantadine Extended-Release Capsules and Candesartan and Hydrochlorothiazide Tablets
Determining the interaction of Amantadine Extended-Release Capsules and Candesartan and Hydrochlorothiazide Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data indicate that thiazide diuretics and/or triamterene may increase the probability of adverse reactions to amantadine. The mechanism is unknown but may be related to reduced clearance of amantadine, resulting in increased plasma levels. Possible reactions include ataxia, confusion, and agitation. If an interaction is suspected, the dosage of amantadine may be reduced or discontinued, or a different diuretic may be substituted.
- Wilson TW, Rajput AH "Amantadine-dyazide interaction." Can Med Assoc J 129 (1983): 974-5
Generic Name: amantadine
Brand name: Gocovri, Osmolex ER, Symmetrel
Synonyms: Amantadine
Generic Name: candesartan / hydrochlorothiazide
Brand name: Atacand HCT
Synonyms: Hydrochlorothiazide and candesartan, Candesartan and Hydrochlorothiazide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amantadine Extended-Release Capsules-Candesartan Cilexetil
- Amantadine Extended-Release Capsules-CanesOral
- Amantadine Extended-Release Capsules-Canges-XP
- Amantadine Extended-Release Capsules-Cangrelor
- Amantadine Extended-Release Capsules-Cangrelor Intravenous
- Amantadine Extended-Release Capsules-Cangrelor tetrasodium
- Candesartan and Hydrochlorothiazide Tablets-Amantadine Extended-Release Tablets
- Candesartan and Hydrochlorothiazide Tablets-Amantadine Hydrochloride
- Candesartan and Hydrochlorothiazide Tablets-Amantadine Oral Solution USP
- Candesartan and Hydrochlorothiazide Tablets-Amantadine Syrup
- Candesartan and Hydrochlorothiazide Tablets-Amantadine Tablets
- Candesartan and Hydrochlorothiazide Tablets-Amaryl