Amantadine Hydrochloride and Quinidine
Determining the interaction of Amantadine Hydrochloride and Quinidine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using amantadine together with quiNIDine may increase the effects of amantadine. Contact your doctor if you experience blurred vision, severe headache, nausea, vomiting, anxiety, confusion, aggression, tremor, fast or uneven heart rate, trouble breathing, or seizure (convulsion). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with quinine or quinidine may decrease the renal clearance of amantadine. The proposed mechanism is quinine and quinidine inhibition of the renal tubular secretion of amantadine. In 18 healthy volunteers administered a single oral dose of amantadine (3 mg/kg), renal clearance of amantadine decreased by approximately 27% and 32% within 6 hours after ingestion of a 200 mg dose of quinine or quinidine, respectively. The interaction was reported only in the male subjects and was not influenced by age.
MANAGEMENT: The potential for increased pharmacologic effects of amantadine, including adverse effects such as dizziness, confusion, ataxia, orthostatic hypotension, dry mouth, nausea and constipation, should be considered during coadministration with quinine or quinidine.
- "Product Information. Symmetrel (amantadine)." DuPont Pharmaceuticals, Wilmington, DE.
- Gaudry SE, Sitar DS, Smyth DD, McKenzie JK, Aoki FY "Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine." Clin Pharmacol Ther 54 (1993): 23-7
Generic Name: amantadine
Brand name: Gocovri, Osmolex ER, Symmetrel
Synonyms: Amantadine
Generic Name: quinidine
Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release
Synonyms: QuiNIDine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amantadine Hydrochloride-Quinidine Controlled-Release Tablets
- Amantadine Hydrochloride-Quinidine Extended Release Tablets
- Amantadine Hydrochloride-Quinidine Gluconate
- Amantadine Hydrochloride-Quinidine Injection
- Amantadine Hydrochloride-Quinidine Oral, Injection, Intramuscular
- Amantadine Hydrochloride-Quinidine Sulfate
- Quinidine-Amantadine Oral Solution USP
- Quinidine-Amantadine Syrup
- Quinidine-Amantadine Tablets
- Quinidine-Amaryl
- Quinidine-Ambator Diclofenac Patch
- Quinidine-Ambator Lidocaine Patch