Amantadine Oral Solution USP and Wellbutrin XL

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using amantadine together with buPROPion can increase the risk of seizures. This may be more likely to occur in older adults or those with a history of seizures or other risk factors for seizures. Risk factor for seizures are: head trauma, excessive use of alcohol or sedatives, addiction to opiates, cocaine, or stimulants, diabetes treated with oral hypoglycemic agents or insulin. Call your doctor if you have symptoms of seizures, muscle stiffness, hallucinations, fainting, fast or uneven heartbeat, shallow breathing, or heart failure. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: The use of bupropion is associated with a dose-related risk of seizures. The estimated incidence of seizures is approximately 0.1% at dosages up to 300 mg/day and 0.4% at dosages between 300 to 450 mg/day, but increases almost tenfold between 450 mg and 600 mg/day. The risk may also be increased during coadministration of bupropion with other potentially epileptogenic agents such as amantadine.

MONITOR CLOSELY: According to the product labeling for bupropion, limited clinical data suggest a higher incidence of adverse experiences in patients receiving bupropion concurrently with either levodopa or amantadine. Neither the mechanism of interaction nor specific adverse effects are cited. According to a published case report, neurotoxic effects including ataxia, dizziness, vertigo, agitation, tremors, and gait abnormalities occurred in 3 elderly patients following addition of amantadine to bupropion therapy. The symptoms resolved within 72 hours after discontinuation of both drugs. The authors theorize that additive central dopaminergic effects of the drugs may have caused the apparent interaction.

MANAGEMENT: Extreme caution is advised if bupropion is administered with amantadine, particularly in the elderly and in patients with a history of seizures or other risk factors for seizures (e.g., head trauma; brain tumor; severe hepatic cirrhosis; metabolic disorders; CNS infections; excessive use of alcohol or sedatives; addiction to opiates, cocaine, or stimulants; diabetes treated with oral hypoglycemic agents or insulin). The manufacturer recommends a lower initial dosage of bupropion and gradual dosage increments in patients receiving the drugs concurrently. The total dose of bupropion should generally not exceed 450 mg/day (or 150 mg every other day in patients with severe hepatic cirrhosis). Bupropion should be discontinued and not restarted in patients who experience a seizure during treatment.

Amantadine Oral Solution USP

Generic Name: amantadine

Brand name: Gocovri, Osmolex ER, Symmetrel

Synonyms: Amantadine

What is Amantadine Oral Solution USP?

Wellbutrin XL

Generic Name: bupropion

Brand name: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Budeprion XL

Synonyms: n.a.

What is Wellbutrin XL?