Ambrisentan and Omeprazole and Sodium Bicarbonate Capsule
Determining the interaction of Ambrisentan and Omeprazole and Sodium Bicarbonate Capsule and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Based on in vitro data, coadministration with potent inhibitors of CYP450 3A4 and/or 2C19 may be expected to increase the plasma concentrations of ambrisentan, which is a substrate of these isoenzymes. However, administration with ketoconazole (potent CYP450 3A4 inhibitor) or omeprazole (potent CYP450 2C19 inhibitor) did not result in clinically relevant changes in ambrisentan exposure.
- "Product Information. Letairis (ambrisentan)." Gilead Sciences, Foster City, CA.
Generic Name: omeprazole / sodium bicarbonate
Brand name: Zegerid, Zegerid OTC
Synonyms: Omeprazole and sodium bicarbonate, Omeprazole and Sodium Bicarbonate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ambrisentan-Omeprazole and Sodium Bicarbonate Capsules
- Ambrisentan-Omeprazole and Sodium Bicarbonate Powder Packets
- Ambrisentan-Omeprazole Delayed-Release Capsules
- Ambrisentan-Omeprazole Delayed-Release Capsules and Tablets (OTC)
- Ambrisentan-Omeprazole Orally-Disintegrating Tablets
- Ambrisentan-Omeprazole Powder for Oral Suspension
- Omeprazole and Sodium Bicarbonate Capsule-Ambrisentan Tablets
- Omeprazole and Sodium Bicarbonate Capsule-Amcinonide
- Omeprazole and Sodium Bicarbonate Capsule-Amcinonide Cream and Ointment
- Omeprazole and Sodium Bicarbonate Capsule-Amcinonide Lotion
- Omeprazole and Sodium Bicarbonate Capsule-Amcinonide Ointment
- Omeprazole and Sodium Bicarbonate Capsule-Amcinonide topical