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Amidate and Pacerone

Determining the interaction of Amidate and Pacerone and the possibility of their joint administration.

Check result:

Amidate <> Pacerone

Relevance: 23.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using amiodarone together with etomidate may increase the risk of cardiovascular complications such as irregular heart rhythm, cardiac conduction abnormalities, and the need for a pacemaker. Close monitoring is required during surgery and until the effects of anesthesia have worn off. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Amiodarone may increase the effect of general anesthetics due to its adrenergic blocking effects. Data have been conflicting; however, the potential for increased risk of intraoperative complications such as arrhythmia, heart block, or pacemaker dependency should be considered.

MANAGEMENT: Cardiorespiratory status should be closely monitored during surgery and until the effects of anesthesia have worn off.

References

Kerin NZ, Aragon E, Faitel K, Frumin H, Rubenfire M "Long-term efficacy and toxicity of high- and low-dose amiodarone regimens." J Clin Pharmacol 29 (1989): 418-23
Liberman BA, Teasdale SJ "Anaesthesia and amiodarone." Can Anaesth Soc J 32 (1985): 629-38
Gallagher JD, Lieberman RW, Meranze J, Spielman SR, Ellison N "Amiodarone-induced complications during coronary artery surgery." Anesthesiology 55 (1981): 186-8

Amidate

Generic Name: etomidate

Brand name: Amidate

Synonyms: n.a.

What is Amidate?

Pacerone

Generic Name: amiodarone

Brand name: Pacerone, Cordarone, Nexterone

Synonyms: n.a.

What is Pacerone?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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