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Amifampridine Tablets (Firdapse) and Exelon

Determining the interaction of Amifampridine Tablets (Firdapse) and Exelon and the possibility of their joint administration.

Check result:

Amifampridine Tablets (Firdapse) <> Exelon

Relevance: 08.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using amifampridine together with rivastigmine may increase certain side effects such as nausea, diarrhea, abdominal pain, muscle weakness, dizziness, drowsiness, and seizures. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of amifampridine with direct or indirect cholinesterase inhibitors may result in additive cholinergic effects and increased adverse reactions such as nausea, diarrhea, abdominal pain, muscle weakness, dizziness, drowsiness, and seizures. Amifampridine may produce cholinergic effects by facilitating the release of acetylcholine from nerve endings and enhancing neuromuscular transmission.

MANAGEMENT: Patients should be apprised of the potential for increased cholinergic effects when amifampridine is coadministered with other drugs that have cholinergic effects such as cholinesterase inhibitors.

References

EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
"Product Information. Firdapse (amifampridine)." Catalyst Pharmaceuticals, Inc., Coral Gables, FL.

Amifampridine Tablets (Firdapse)

Generic Name: amifampridine

Brand name: Firdapse, Ruzurgi

Synonyms: Amifampridine

What is Amifampridine Tablets (Firdapse)?

Exelon

Generic Name: rivastigmine

Brand name: Exelon

Synonyms: n.a.

What is Exelon?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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