Amifostine Intravenous and Nitrolingual

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

If you are currently being treated with nitroglycerin, let your doctor know before you receive amifostine. Combining these medications may have additive effects in lowering your blood pressure. Depending on your condition, your doctor may want you to discontinue nitroglycerin for 24 hours before you receive treatment with amifostine, and your blood pressure will need to be monitored closely during and after the treatment. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Contact your doctor if you develop these symptoms and they do not go away after a few hours, or they become troublesome. You should avoid rising abruptly from a sitting or lying position until you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Concomitant use with hypotensive agents may increase the risk and severity of hypotension associated with amifostine. Hypotension has been reported frequently in patients treated with amifostine. It is usually transient (lasting from 5 to 15 minutes) and closely associated with amifostine administration, but may persist or become evident hours after administration. Moreover, hypotension can occur despite adequate hydration and positioning of the patient. Significant drops in systolic blood pressure have been reported, in some cases resulting in premature termination of amifostine infusion. In rare cases, sometimes during or after hypotension, patients have experienced tachycardia, bradycardia, dyspnea, apnea, hypoxia, chest pain, myocardial ischemia, renal failure, myocardial infarction, convulsions, unconsciousness, respiratory arrest, and cardiac arrest.

MANAGEMENT: If medically feasible, antihypertensive medications should be interrupted 24 hours prior to amifostine administration. Blood pressure should be closely monitored during and after treatment. In addition to hypotension, transient hypertension or exacerbation of preexisting hypertension may occur from intravenous hydration, discontinuation of antihypertensive medications, or other causes. Patients who continue their hypotensive medication(s) during amifostine therapy should be carefully monitored for the development of hypotension. Clinical symptoms of hypotension are usually quickly reversed by fluid infusion and postural management.

Amifostine Intravenous

Generic Name: amifostine

Brand name: Ethyol

Synonyms: Amifostine

What is Amifostine Intravenous?

Nitrolingual

Generic Name: nitroglycerin

Brand name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: n.a.

What is Nitrolingual?