Amikacin liposome and Tranylcypromine Sulfate

• Generic Name: amikacin liposome
• Dosage Forms: n.a.
• Other Brand Names: Arikayce

Amikacin liposome is an antibiotic that is used to treat Mycobacterium avium complex (MAC) lung disease in adults who have few or no other treatment options. Amikacin liposome is given in combination with other antibiotics.

Amikacin liposome is given only to certain adults, when other antibiotics have failed to clear their MAC infections after 6 months of treatment.

Amikacin liposome was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to amikacin liposome, but further studies are needed.

Amikacin liposome may also be used for purposes not listed in this medication guide.

• Generic Name: tranylcypromine
• Dosage Forms: n.a.
• Other Brand Names: Parnate

Treatment of major depressive disorder without melancholia.

Efficacy in major depressive disorder with melancholia (endogenous features) not established.

MAO inhibitors appear particularly effective in treatment of major depressive disorder with atypical features, although other antidepressants (e.g., SSRIs) may initially be used because of their more favorable adverse effect profile.

Because of potential for serious adverse effects and necessity of dietary restrictions, MAO inhibitors (e.g., phenelzine, tranylcypromine) generally are not used as initial therapy for major depressive disorder, but are reserved for carefully selected patients who can be closely supervised and who have depression refractory to other antidepressants (e.g., SSRIs, SNRIs, TCAs) or in whom other therapies are contraindicated.