Amikin and Ethacrynate sodium Intravenous
Determining the interaction of Amikin and Ethacrynate sodium Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Amikacin can cause hearing loss, ringing in the ears, vertigo, and kidney problems, and combining it with certain diuretics like ethacrynic acid may increase the risks. Patients who may be particularly susceptible include the elderly and those who are dehydrated or have preexisting kidney disease. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration of parenteral or inhaled aminoglycoside antibiotics or oral neomycin in combination with loop diuretics may potentiate the risk of oto- or nephrotoxicity due to additive or synergistic pharmacologic effects of these drugs and or altered aminoglycoside serum and tissue levels. Coadministration of aminoglycosides with intravenous mannitol may increase the risk of nephrotoxicity. The risk may be greater with high dosages of either drug, preexisting renal insufficiency, advanced age, dehydration, or the presence of other oto- or nephrotoxic drugs. The onset of ototoxicity may be greatly delayed, and cochlear damage may initially be asymptomatic. Reversible and irreversible hearing losses have been reported with aminoglycosides and loop diuretics.
MANAGEMENT: The use of aminoglycoside antibiotics in combination with loop diuretics or intravenous mannitol should generally be avoided. Renal function tests and serial, vestibular, and audiometric tests should be performed as appropriate for the type of diuretic before and during therapy if coadministration is necessary.
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Generic Name: ethacrynic acid
Brand name: Edecrin, Edecrin Sodium, Sodium Edecrin
Synonyms: Ethacrynic acid, Ethacrynic Acid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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