Amiloride and Hydrochlorothiazide and Magnesium hydroxide
Determining the interaction of Amiloride and Hydrochlorothiazide and Magnesium hydroxide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: The chronic use or abuse of laxatives may potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes, including sodium, potassium, magnesium and zinc, and these effects may be additive to those of diuretics. MANAGEMENT: In general, laxatives should only be used on a short-term, intermittent basis in recommended dosages. During concomitant use with diuretics, patients should be advised to contact their physician if they experience signs and symptoms of fluid and electrolyte depletion such as dizziness, lightheadedness, dry mouth, thirst, fatigue, weakness, lethargy, muscle cramps, decreased urination, postural hypotension, and tachycardia. If maintenance of bowel regularity is required, patients should be advised to exercise and increase fiber in the diet and/or consider the use of bulk-forming laxatives. References Blumenthal M, Goldberg A, Brinckmann J, eds. "Herbal Medicine: Expanded Commission E Monographs." Newton, MA: Integrative Medicine Communications (2000): Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45 Leary WP, Reyes AJ "Drug interactions with diuretics." S Afr Med J 65 (1984): 455-61 Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8 Atsmon J, Dolev E "Drug-induced hypomagnesaemia : scope and management." Drug Saf 28 (2005): 763-88 View all 5 references
Professional:MONITOR: The chronic use or abuse of laxatives may potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes, including sodium, potassium, magnesium and zinc, and these effects may be additive to those of diuretics.
MANAGEMENT: In general, laxatives should only be used on a short-term, intermittent basis in recommended dosages. During concomitant use with diuretics, patients should be advised to contact their physician if they experience signs and symptoms of fluid and electrolyte depletion such as dizziness, lightheadedness, dry mouth, thirst, fatigue, weakness, lethargy, muscle cramps, decreased urination, postural hypotension, and tachycardia. If maintenance of bowel regularity is required, patients should be advised to exercise and increase fiber in the diet and/or consider the use of bulk-forming laxatives.
- Blumenthal M, Goldberg A, Brinckmann J, eds. "Herbal Medicine: Expanded Commission E Monographs." Newton, MA: Integrative Medicine Communications (2000):
- Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45
- Leary WP, Reyes AJ "Drug interactions with diuretics." S Afr Med J 65 (1984): 455-61
- Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8
- Atsmon J, Dolev E "Drug-induced hypomagnesaemia : scope and management." Drug Saf 28 (2005): 763-88
Generic Name: amiloride / hydrochlorothiazide
Brand name: Moduretic 5-50
Synonyms: Hydrochlorothiazide and amiloride
Generic Name: magnesium hydroxide
Brand name: Ex-Lax Milk of Magnesia, Milk of Magnesia, Pedia-Lax Chewable, Phillips Milk of Magnesia, Concentrated Phillips Milk of Magnesia, Dulcolax Milk of Magnesia
Synonyms: Magnesium Hydroxide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amiloride and Hydrochlorothiazide-Magnesium Hydroxide and Mineral Oil
- Amiloride and Hydrochlorothiazide-Magnesium Hydroxide Chewable Tablets
- Amiloride and Hydrochlorothiazide-Magnesium Hydroxide Suspension
- Amiloride and Hydrochlorothiazide-Magnesium L-aspartate Hydrochloride
- Amiloride and Hydrochlorothiazide-Magnesium L-Aspartate Hydrochloride Powder Packets
- Amiloride and Hydrochlorothiazide-Magnesium L-Aspartate Hydrochloride Tablets
- Magnesium hydroxide-Amiloride Hydrochloride
- Magnesium hydroxide-Amino Acid Injection
- Magnesium hydroxide-Amino acids and electrolytes in dextrose with calcium Intravenous
- Magnesium hydroxide-Amino acids in dextrose Intravenous
- Magnesium hydroxide-Amino-CR
- Magnesium hydroxide-Amino-Opti-C