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Amiloride and Hydrochlorothiazide and Trimox

Determining the interaction of Amiloride and Hydrochlorothiazide and Trimox and the possibility of their joint administration.

Check result:

Amiloride and Hydrochlorothiazide <> Trimox

Relevance: 09.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Amiloride may decrease the absorption and the bioavailability of amoxicillin. The efficacy of amoxicillin may be reduced. The mechanism appears to be an amiloride-induced reduction in the transport system needed for beta-lactam antibiotics. No specific action is needed if amiloride and amoxicillin are coadministered, but the patient should be monitored for reduced antibiotic efficacy.

References

Westphal JF, Jehl F, Brogard JM, Carbon C "Amoxicillin intestinal absorption reduction by amiloride: possible role of the na+-h+ exchanger." Clin Pharmacol Ther 57 (1995): 257-64

Amiloride and Hydrochlorothiazide

Generic Name: amiloride / hydrochlorothiazide

Brand name: Moduretic 5-50

Synonyms: Hydrochlorothiazide and amiloride

What is Amiloride and Hydrochlorothiazide?

Trimox

Generic Name: amoxicillin

Brand name: Moxatag, Trimox, Amoxil

Synonyms: n.a.

What is Trimox?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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