Aminocaproic Acid Tablets and Urokinase Intravenous
Determining the interaction of Aminocaproic Acid Tablets and Urokinase Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using aminocaproic acid together with urokinase may reduce the effectiveness of both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of an antifibrinolytic agent (e.g., aminocaproic acid, tranexamic acid, aprotinin) in combination with a tissue plasminogen activator (t-PA) may reduce the therapeutic effects of both drugs due to opposing pharmacodynamic actions. Aminocaproic acid and tranexamic acid are competitive inhibitors of plasminogen activation. At high concentrations they can also directly inhibit plasmin, which is needed for the degradation of fibrin and thrombolysis. Aprotinin is a broad-spectrum protease inhibitor that inhibits plasmin. It is known to have antifibrinolytic activity and may interact with t-PAs in a similar fashion.
MANAGEMENT: No specific intervention is warranted, but clinicians should be alert to the potential for diminished therapeutic efficacy if a tissue plasminogen activator is administered to a patient who has been treated with an antifibrinolytic agent, and vice versa.
- "Product Information. LYSTEDA (tranexamic acid)." Xanodyne Pharmaceuticals Inc, Newport, KY.
- "Product Information. Cyklokapron (tranexamic acid)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Trasylol (aprotinin)." Bayer, West Haven, CT.
- "Product Information. Amicar (aminocaproic acid)." Immunex Corporation, Seattle, WA.
Generic Name: aminocaproic acid
Brand name: Amicar
Synonyms: Aminocaproic acid, Aminocaproic Acid
Generic Name: urokinase
Brand name: Kinlytic, Abbokinase, Abbokinase Open-Cath
Synonyms: Urokinase
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aminocaproic Acid Tablets-Urolet MB
- Aminocaproic Acid Tablets-Urophen MB
- Aminocaproic Acid Tablets-Uroxatral
- Aminocaproic Acid Tablets-Urso
- Aminocaproic Acid Tablets-Urso 250
- Aminocaproic Acid Tablets-Urso Forte
- Urokinase Intravenous-Aminofen
- Urokinase Intravenous-Aminoglutethimide
- Urokinase Intravenous-Aminolevulinic acid
- Urokinase Intravenous-Aminolevulinic Acid (Systemic)
- Urokinase Intravenous-Aminolevulinic Acid Gel
- Urokinase Intravenous-Aminolevulinic Acid Hydrochloride