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Aminoglutethimide and Aminophylline

Determining the interaction of Aminoglutethimide and Aminophylline and the possibility of their joint administration.

Check result:
Aminoglutethimide <> Aminophylline
Relevance: 19.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using aminophylline together with aminoglutethimide can decrease the effects of aminophylline. Contact your doctor if your conditions worsens. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Aminoglutethimide may significantly reduce theophylline serum concentrations by increasing theophylline clearance. The mechanism is induction of CYP450 3A4 hepatic microsomal enzymes. One study noted an increase of 32% in theophylline clearance. Conversely, theophylline toxicity may occur after aminoglutethimide is discontinued.

MANAGEMENT: The patient should be monitored for clinical and laboratory evidence of altered theophylline response when aminoglutethimide is added, discontinued, or the dosage is changed. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms during concurrent therapy.

References
  • Lonning PE, Kvinnsland S, Bakke OM "Effect of aminoglutethimide on antipyrine, theophylline, and digitoxin disposition in breast cancer." Clin Pharmacol Ther 36 (1984): 796-802
Aminoglutethimide

Generic Name: aminoglutethimide

Brand name:

Synonyms: Aminoglutethimide (Oral)

Aminophylline

Generic Name: aminophylline

Brand name: Phyllocontin, Truphylline

Synonyms: Aminophylline (injection)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction