Aminoglutethimide and Jantoven

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using warfarin together with aminoglutethimide can decrease the effects of warfarin. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). It is important that you tell your doctor about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

MONITOR: Aminoglutethimide may significantly increase warfarin clearance by induction of CYP450 2C9 and/or 3A4 hepatic microsomal enzymes. In one study, warfarin clearance increased three- to fivefold. A similar effect may occur with other oral anticoagulants.

MANAGEMENT: The patient should be monitored for reduced anticoagulant effect when aminoglutethimide is added, discontinued, or the dosage is changed. Patients should be advised to promptly report any signs of blood clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).

Aminoglutethimide

Generic Name: aminoglutethimide

Brand name:

Synonyms: Aminoglutethimide (Oral)

What is Aminoglutethimide?

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Jantoven?