Aminophylline injection and Imipenem and cilastatin Intravenous, Intramuscular
Determining the interaction of Aminophylline injection and Imipenem and cilastatin Intravenous, Intramuscular and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using aminophylline together with imipenem may cause seizures. Contact your doctor if you experience confusion, seizures, and other mental status changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Some case reports suggest an increased risk of seizures when theophylline and imipenem are coadministered. The mechanism is unknown. Patients receiving large doses of either drug and/or with renal dysfunction may be at a higher risk.
MANAGEMENT: Dosing should be individualized and patients should be closely monitored for signs of neurotoxicity (e.g., confusion, seizures, myoclonic activity).
- Semel JD, Allen N "Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole." South Med J 84 (1991): 465-8
Generic Name: aminophylline
Brand name: Phyllocontin, Truphylline
Synonyms: Aminophylline (injection), Aminophylline
Generic Name: cilastatin / imipenem
Brand name: Primaxin IV, Primaxin IM, Primaxin IV ADD-Vantage
Synonyms: Imipenem and cilastatin, Imipenem and Cilastatin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aminophylline injection-Imipenem, Cilastatin, and Relebactam
- Aminophylline injection-Imipramine
- Aminophylline injection-Imipramine Capsules
- Aminophylline injection-Imipramine Hydrochloride
- Aminophylline injection-Imipramine Pamoate
- Aminophylline injection-Imipramine Tablets
- Imipenem and cilastatin Intravenous, Intramuscular-Aminophylline Intravenous
- Imipenem and cilastatin Intravenous, Intramuscular-Aminophylline Oral Solution
- Imipenem and cilastatin Intravenous, Intramuscular-Aminophylline Tablets
- Imipenem and cilastatin Intravenous, Intramuscular-AminoProtect
- Imipenem and cilastatin Intravenous, Intramuscular-Aminosalicylate sodium
- Imipenem and cilastatin Intravenous, Intramuscular-Aminosalicylic Acid