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Aminophylline injection and Riluzole

Determining the interaction of Aminophylline injection and Riluzole and the possibility of their joint administration.

Check result:
Aminophylline injection <> Riluzole
Relevance: 25.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

According to the manufacturer, riluzole serum concentrations may theoretically be increased by concurrent theophylline and aminophylline. The proposed mechanism is metabolic inhibition. The clinical significance of this interaction is not known. The patient should be monitored for altered clinical effect. Dosage adjustments may be necessary if an interaction is suspected.

References
  • "Product Information. Rilutek (riluzole)." Rhone-Poulenc Rorer, Collegeville, PA.
Aminophylline injection

Generic Name: aminophylline

Brand name: Phyllocontin, Truphylline

Synonyms: Aminophylline (injection), Aminophylline

Riluzole

Generic Name: riluzole

Brand name: Rilutek, Tiglutik

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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