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Aminophylline Intravenous and Nizoral

Determining the interaction of Aminophylline Intravenous and Nizoral and the possibility of their joint administration.

Check result:

Aminophylline Intravenous <> Nizoral

Relevance: 24.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration of ketoconazole with a slow-release preparation of theophylline has been reported to decrease serum theophylline concentration. The mechanism may be related to decreased absorption. Ketoconazole has not been shown to interfere with the pharmacokinetics of intravenous theophylline. Theophylline dosages should be adjusted if necessary. Patients should be monitored for altered efficacy of theophylline if ketoconazole is added to their regimen.

References

Heusner JJ, Dukes GE, Rollins DE, et al "Effect of chronically administered ketoconazole on the elimination of theophylline in man." Drug Intell Clin Pharm 21 (1987): 514-7
Brown MW, Maldonado AL, Meredith CG, Speeg KV "Effect of ketoconazole on hepatic oxidative drug metabolism." Clin Pharmacol Ther 37 (1985): 290-7

Aminophylline Intravenous

Generic Name: aminophylline

Brand name: Phyllocontin, Truphylline

Synonyms: Aminophylline (Intravenous)

What is Aminophylline Intravenous?

Nizoral

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: n.a.

What is Nizoral?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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