Aminophylline Oral Solution and First - Lansoprazole
Determining the interaction of Aminophylline Oral Solution and First - Lansoprazole and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Lansoprazole may cause a minor decrease in the area under the plasma concentration-time curve of theophylline and related drugs. This effect appears to be small (approximately a 13% decrease in one study) and may be related either to a reduction in absorption or to enhanced clearance caused by induction of hepatic enzymes by lansoprazole. Dosage adjustment is not believed to be necessary. However, close observation for evidence of altered methylxanthine effect is recommended.
- Kokufu T, Ihara N, Sugioka N, Koyama H, Ohta T, Mori S, Nakajima K "Effects of lansoprazole on pharmacokinetics and metabolism of theophylline." Eur J Clin Pharmacol 48 (1995): 391-5
- Granneman GR, Karol MD, Locke CS "Pharmacokinetic interaction between lansoprazole and theophylline." Ther Drug Monit 17 (1995): 460-4
- "Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc, Deerfield, IL.
- Ko JW, Jang IJ, Shin JG, Nam SK, Shin SG, Flockhart DA "Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers." Clin Pharmacol Ther 65 (1999): 606-14
Generic Name: aminophylline
Brand name: Phyllocontin, Truphylline
Synonyms: Aminophylline (injection), Aminophylline
Generic Name: lansoprazole
Brand name: FIRST Lansoprazole, Prevacid, Prevacid OTC, Prevacid SoluTab
Synonyms: Lansoprazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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