Aminophylline Tablets and Deferasirox Tablets For Oral Suspension
Determining the interaction of Aminophylline Tablets and Deferasirox Tablets For Oral Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Deferasirox may significantly increase the blood levels of aminophylline, which may lead to potentially serious and life-threatening side effects. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you develop nausea, vomiting, diarrhea, loss of appetite, headache, tremor, confusion, restlessness, insomnia, seizures, heart palpitations, and/or irregular heartbeat, as these may be signs and symptoms of excessive aminophylline levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with deferasirox may significantly increase the plasma concentrations of theophylline. The proposed mechanism is deferasirox inhibition of CYP450 1A2, the isoenzyme primarily responsible for the metabolic clearance of theophylline. In a study of healthy volunteers, administration of a single 120 mg dose of theophylline in combination with deferasirox (repeated dosing of 30 mg/kg/day) resulted in an approximate doubling of theophylline systemic exposure (AUC) and elimination half-life. The single-dose peak plasma concentration (Cmax) was not affected, but an increase in theophylline Cmax is expected to occur with chronic dosing.
MANAGEMENT: Given the potential risk for theophylline toxicity, concomitant use with deferasirox should generally be avoided. Dosage adjustment for theophylline may be needed if coadministration with deferasirox is required. Close monitoring of serum theophylline levels is recommended, particularly following the addition, discontinuation, or change of dosage of deferasirox. Patients should be advised to notify their physician if they experience signs of theophylline toxicity such as nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, palpitations, and cardiac arrhythmia.
- "Product Information. Exjade (deferasirox)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: aminophylline
Brand name: Phyllocontin, Truphylline
Synonyms: Aminophylline (injection), Aminophylline
Generic Name: deferasirox
Brand name: Exjade, Jadenu, Jadenu Sprinkle
Synonyms: Deferasirox
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Aminophylline Tablets-Deferiprone
- Aminophylline Tablets-Deferiprone Oral Solution
- Aminophylline Tablets-Deferiprone Tablets
- Aminophylline Tablets-Deferoxamine
- Aminophylline Tablets-Deferoxamine Injection
- Aminophylline Tablets-Deferoxamine Mesylate
- Deferasirox Tablets For Oral Suspension-AminoProtect
- Deferasirox Tablets For Oral Suspension-Aminosalicylate sodium
- Deferasirox Tablets For Oral Suspension-Aminosalicylic Acid
- Deferasirox Tablets For Oral Suspension-Aminosyn
- Deferasirox Tablets For Oral Suspension-Aminosyn 10%
- Deferasirox Tablets For Oral Suspension-Aminosyn II