Aminophylline Tablets and Fluzone 2015-2016 Formula
Determining the interaction of Aminophylline Tablets and Fluzone 2015-2016 Formula and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that administration of split, trivalent influenza vaccine may cause a transient reduction in theophylline clearance. However, further studies have not been able to reproduce this interaction. Patients should be monitored for possible theophylline toxicity following influenza vaccination. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians.
- Gomolin IH, Chapron DJ, Luhan PA "Lack of effect of influenza vaccine on theophylline levels and warfarin anticoagulation in the elderly." J Am Geriatr Soc 33 (1985): 269-72
- Patriarca PA, Kendal AP, Stricof RL, Weber JA, Meissner MK, Dateno B "Influenza vaccination and warfarin or theophylline toxicity in nursing home patients." N Engl J Med 308 (1983): 1601-2
- Grabowski N, May JJ, Pratt DS, Richtsmeier WJ, Bertino Jr JS "The effect of split virus influenza vaccination on theophylline pharmacokinetics." Am Rev Respir Dis 131 (1985): 934-8
- Bukowskyj M, Munt PW, Wigle R, Nakatsu K "Theophylline clearance: lack of effect of influenza vaccination and ascorbic acid." Am Rev Respir Dis 129 (1984): 672-5
- Meredith CG, Christian CD, Johnson RF, Troxell R, Davis GL, Schenker S "Effects of influenza virus vaccine on hepatic drug metabolism." Clin Pharmacol Ther 37 (1985): 396-401
- Winstanley PA, Tjia J, Back DJ, Hobson D, Breckenridge AM "Lack of effect of highly purified subunit influenza vaccination on theophylline metabolism." Br J Clin Pharmacol 20 (1985): 47-53
- Renton KW, Gray JD, Hall RI "Decreased elimination of theophylline after influenza vaccination." Can Med Assoc J 123 (1980): 288-90
- Jonkman JHG, Wymenga ASC, de Zeeuw RA, et al. "No effect of influenza vaccination on theophylline pharmacokinetics as studied by ultraviolet spectrophotometry, HPLC, and EMIT assay methods." Ther Drug Monit 10 (1988): 345-48
Generic Name: aminophylline
Brand name: Phyllocontin, Truphylline
Synonyms: Aminophylline (injection), Aminophylline
Generic Name: influenza virus vaccine, inactivated
Brand name: Afluria, Agriflu, Fluad 2019-2020, Fluarix, Flublok Quadrivalent 2019-2020, Flucelvax, FluLaval, Fluogen, Flushield, Fluvirin, Fluzone, Flucelvax, Fluzone Intradermal Quadrivalent, Fluzone Quadrivalent, Flublok, Flublok Quadrivalent
Synonyms: Influenza virus vaccine (injection), Influenza Virus Vaccine (Inactivated)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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