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Aminophylline Tablets and Isoniazid

Determining the interaction of Aminophylline Tablets and Isoniazid and the possibility of their joint administration.

Check result:

Aminophylline Tablets <> Isoniazid

Relevance: 28.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using isoniazid together with aminophylline can increase the effects of aminophylline. You should contact your doctor if you experience nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or an irregular heartbeat. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Theophylline serum concentrations may be gradually increased by concomitant isoniazid administration. The mechanism is thought to involve isoniazid-induced inhibition of the CYP450 3A4 and 1A2 hepatic metabolism of theophylline.

MANAGEMENT: Clinical monitoring of patient response and tolerance and serum theophylline levels is recommended when isoniazid is added. Patients should be advised to report any signs of theophylline toxicity to their caregiver, including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat.

References

Dal Negro R, Turco P, Trevisan F, De Conti F "Rifampicin-isoniazid and delayed elimination of theophylline: a case report." Int J Clin Pharmacol Res 8 (1988): 275-7
Hoglund P, Nilsson LG, Paulson O "Interaction between isoniazid and theophylline." Eur J Respir Dis 70 (1987): 110-6
Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet 20 (1991): 66-80
Torrent J, Izquierdo I, Cabezas R, Jane F "Theophylline-isoniazid interaction." DICP 23 (1989): 143-5

Aminophylline Tablets

Generic Name: aminophylline

Brand name: Phyllocontin, Truphylline

Synonyms: Aminophylline (injection), Aminophylline

What is Aminophylline Tablets?

Isoniazid

Generic Name: isoniazid

Brand name: Nydrazid

Synonyms: n.a.

What is Isoniazid?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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