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Aminosalicylic Acid and LA-12

Determining the interaction of Aminosalicylic Acid and LA-12 and the possibility of their joint administration.

Check result:
Aminosalicylic Acid <> LA-12
Relevance: 03.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data suggest that aminosalicylic acid may decrease the gastrointestinal absorption of vitamin B12. This interaction is not proven, but is theoretically possible due to a mild malabsorption syndrome that can occur in some patients treated with aminosalicylic acid. However, it should rarely lead to clinically significant deficiency because the body (primarily the liver) usually has a copious supply of vitamin B12 that can sustain a person for several years in the absence of adequate intake. As for the treatment of B12 deficiency-related anemia, non-oral routes of administration (e.g., parenteral, intranasal, sublingual) are generally preferred, which would bypass the potential interaction.

References
  • Heinivaara O "Malabsorption of vitamin B112 during treatment with para-aminosalicylic acid: a preliminary report." Acta Med Scand 175 (1964): 469-71
  • Halsted CH, McIntyre PA "Intestinal malabsorption caused by aminosalicylic acid therapy." Arch Intern Med 130 (1972): 935-9
  • Palva IP, Rytkonen U, Slatulkkila M, Palva M "Drug-induced malabsorption of vitamin B12." Scand J Haematol 9 (1972): 5-7
  • Levine RA, "Steatorrhea induced by para-aminosalicylic acid." Ann Intern Med 68 (1968): 1265
Aminosalicylic Acid

Generic Name: aminosalicylic acid

Brand name: Paser

Synonyms: n.a.

LA-12

Generic Name: cyanocobalamin

Brand name: Cobolin-M, Depo-Cobolin, Vitamin B12, B-12 Dots, Nascobal, Cobal 1000, Vitamin B-12

Synonyms: LA-12 (Intramuscular)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction